RENOVA 0.02% CREAM NOW AVAILABLE BY PRESCRIPTION

November 2000 - RENOVA® (tretinoin cream) 0.02%, which was approved by the U.S. Food & Drug Administration in August, is now available by prescription. The new RENOVA formulation is effective in reducing fine facial wrinkles when used as part of a total skin care and sun protection program. It is marketed by Ortho Dermatological, a member of the Johnson & Johnson Family of Companies.

RENOVA is the only prescription cream proven to reduce fine facial wrinkles associated with chronic sun exposure and the natural aging process. Studies demonstrate that nightly therapy with RENOVA 0.02% significantly improves fine facial wrinkles, such as crow's-feet.

RENOVA 0.02% contains the active ingredient tretinoin (a Vitamin A derivative like the one naturally occurring in the body), in a light, cosmetically elegant oil-in-water cream.

An expert's opinion
"In my practice, I recommend that all my patients aged 30-plus start an anti-aging treatment program. I often recommend sunscreen, moisturizer, and RENOVA as the three 'must do's' for women interested in improving their appearance," says Deborah S. Sarnoff, M.D., F.A.A.D., F.A.C.P., Assistant Clinical Professor of Dermatology at the New York University School of Medicine, and co-author of Beauty and the Beam: Your Complete Guide to Cosmetic Laser Surgery. "The new RENOVA formulation is an ideal starting point for people interested in improving the appearance of their skin."

RENOVA 0.02% is clinically tested
Six-hundred-and-fifty-six subjects between the ages of 45 and 70 who showed signs of moderate to severe photodamage participated in the randomized, multi-center, double-blind, clinical studies for RENOVA 0.02%. Subjects received treatment for up to 24 weeks with RENOVA 0.02% or a placebo, in conjunction with a comprehensive skin care and sun protection program. Based on investigator evaluations, subject self-assessments and independent computer-generated skin replica measures, RENOVA 0.02% exhibited significantly better improvement than placebo in treating fine facial wrinkles in Caucasian and other lightly-pigmented subjects.

What to expect
People who respond to RENOVA 0.02% Cream may begin to notice their skin becoming smoother and softer within the first month or two. Within two to three months, users may notice a reduction in fine facial wrinkles. Additional benefits should be apparent within five to six months of therapy. Continued use of the product beyond six months can help maintain the visible improvement.

"People using RENOVA generally experience some redness, itching, dryness, or flaking before seeing visible improvement," explains Dr. Sarnoff. "These signs and symptoms are usually mild and well tolerated and decrease as treatment continues." In some patients, this may be severe. Patients who find skin irritation to be a problem should contact their doctor.

People who discontinue RENOVA therapy for more than 12 weeks may lose some of the product's effects. Once therapy is restarted, users should continue to see improvement.

Like other prescription medications, RENOVA 0.02% Cream has been tested for safety and effectiveness. While it will not repair sun damaged skin, eliminate wrinkles, or reverse the aging process, it is proven to reduce fine facial wrinkles when used as part of a total skin care regimen, including sunscreen.

RENOVA Cream 0.02% is a dermal irritant. It has been proven effective in clinical trials lasting 12 months in Caucasians and other lightly-pigmented subjects. Effectiveness beyond 12 months has not been established in controlled clinical trials.

RENOVA 0.02% is not appropriate for everyone, so talk to your doctor if you are pregnant, nursing, or on other medications such as drug(s) known to be photosensitizers.

For more information about RENOVA, call 1-800-64-RENOVA (647-3668).